普罗梅塔对手术前和手术内裂 palatal 手术中的后果的有效性
A Vedha Vivigdha1, P Senthil Murugan2, M P Santhosh Kumar2
1Department of Oral and Maxillofacial Surgery, Saveetha Oral Cancer Institute, Saveetha Institute of Medical And Technical Sciences (SIMATS), Saveetha University, Chennai, Tamli Nadu, India.
Orthodontics & craniofacial research
|January 24, 2024
概括
普罗米塔显著降低了手术前的焦虑,并改善了接受裂手术的儿童的睡眠. 这种抗胰岛素对于治疗儿科患者手术后果是安全有效的.
科学领域:
- 儿科手术 儿科手术
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿童的口腔裂手术与显著的手术前焦虑和医院感染有关.
- 抗组胺剂的使用,如普罗米他辛,用于管理儿童上呼吸道感染仍在争论中.
- 作为第一代H1抗剂的promethazine具有显著的镇静作用.
研究的目的:
- 评估普罗梅他辛在减轻儿科裂 palatal 手术中的手术前和手术内并发症的有效性.
- 评估普罗梅他辛对焦虑,睡眠质量和咳率的影响.
- 在裂口 palatal 修复期间监测手术内心率稳定性.
主要方法:
- 一个单中心,并行,随机,双盲的受控试验,涉及128名2至4岁的儿童接受裂手术.
- 参与者接受了前列糖 (每天两次1毫克/公斤,持续3天) 或安慰剂.
- 结果包括手术前焦虑 (儿童恐惧量表),睡眠质量,咳率和手术内心率 (心电图监测).
主要成果:
- 普罗米塔辛的使用导致了手术前焦虑水平的70%降低.
- 观察到感冒和咳症状减少了64%,睡眠得分改善了70%.
- 在 promethazine 组中,手术期间心率在整个手术过程中保持稳定.
结论:
- 普罗米特因被认为是安全有效的,作为儿科口腔裂手术的前期药物.
- 普罗马在治疗手术后果方面的好处超过了潜在的不良影响.
- 这项研究支持使用普罗梅来改善患者在口腔裂修复的结果.
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