砂机中的加速化:病理学,矿物学和临床相关性
Judith A Crawford1, Soma Sanyal1, Bryan R Burnett2
1Department of Pathology, SUNY Upstate Medical University, Syracuse, New York, USA.
American journal of industrial medicine
|January 24, 2024
概括
加快的症可以发生在正常的胸部X射线上,显示炎症和肺部损伤. 暴露于,特别是从回收沙子中暴露的,导致油田工人的严重疾病进展.
科学领域:
- 职业医学 职业医学 职业医学
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
背景情况:
- 在暴露于的工人中,越来越多的报告报告了加速的病和自身免疫性疾病.
- 专注于德克萨斯州油田管道沙吹机的肺病理.
- 在1988-1995年间对46名工人进行了活检的研究.
研究的目的:
- 描述加速症的肺病理学.
- 与矿物学,放射学和疾病进展相关联病理学.
- 调查油田管道沙吹机中的二氧化暴露情况.
主要方法:
- 工人检查:肺功能测试,胸部X射线 (CXR),高分辨率计算机断层扫描 (HRCT),-67扫描.
- 使用SEM EDS.进行肺负荷 (,酸盐,金属) 的量化矿物学分析.
- 肺组织的组织病理学分析.
主要成果:
- 暴露时间<10年后的临床恶化.
- 54%的CXR正常,但68%的-67扫描结果呈阳性,表明炎症.
- 组织学显示了巨细胞透,状结节或膜蛋白质.
- 肺部二氧化和放射/病理变化之间的剂量反应关系.
- 恶化放射学分数和扩散能力.
- 循环砂暴露与更年轻的发病,更短的暴露和更快的进展有关.
结论:
- 加快的病可以表现为正常的CXR,尽管有显著的组织病理学.
- ,而不是其他颗粒,驱动放射学,生理学和组织学结果.
- 消除这种可预防的疾病需要医生,公共卫生和社会提高意识.
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