肝纤维化:病理特征,临床治疗和治疗纳米剂的应用
Lin Chen1, Wenyan Guo1, Chun Mao1
1National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. maochun@njnu.edu.cn.
Journal of materials chemistry. B
|January 24, 2024
概括
纳米材料提供了一个有前途的新方法来治疗肝纤维化,通过实现向药物输送. 需要进一步的研究来证实这些创新的纳米疗法的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 纳米技术 纳米技术
背景情况:
- 肝纤维化涉及肝细胞损伤,鼻状毛细化,激活的肝星细胞,细胞外矩阵积累和炎症.
- 目前的治疗方法,如药物和干细胞疗法,显示出有希望的结果,但需要更多的临床验证.
- 基于纳米材料的疗法正在成为肝纤维化治疗的新替代方案.
研究的目的:
- 审查肝纤维化的病理特征.
- 在临床试验中引入当前的抗纤维化药物.
- 详细介绍治疗纳米剂,用于精确的抗纤维化药物输送.
主要方法:
- 关于肝纤维化病理学的现有文献的综述.
- 对抗纤维化药物的当前临床试验数据的分析.
- 探索用于药物输送应用的天然和合成纳米材料.
主要成果:
- 纳米材料,包括细胞外囊泡,无机和有机纳米颗粒,可以促进向药物输送和肝纤维化组合疗法.
- 这些纳米疗法为克服传统治疗方法的局限性提供了一个有希望的途径.
结论:
- 纳米材料代表了开发先进肝纤维化疗法的创新策略.
- 使用纳米剂的精确药物输送是提高治疗疗效的关键.
- 未来的研究应该专注于基于纳米材料的干预措施的临床转化和优化.
相关概念视频
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
01:27Liver Histology
793
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
793
01:30Liver Physiology
554
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
554
01:26Diseases of the Liver and Gallbladder
540
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
540