血清TNF-α水平和探测深度作为周植入疾病的综合指标
Huerxidai Yilihamujiang1, Xiaofeng Ni1, Mingkai Yu2
1Department of Prosthodontics and Dental Implant, Xinjiang Medical University Affiliated First Hospital, School of Stomatology, Xinjiang Uyghur Autonomous Region, Urumqi, China.
概括
瘤亡因子-α (TNF-α) 和探测深度 (PD) 是围部植入体疾病 (PID) 的关键指标. 提升的TNF-α和PD水平预测PID严重程度,有助于诊断和进展监测.
科学领域:
- 口腔植入物学口腔植入物学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 牙周植入物疾病 (PID) 涵盖了影响牙科植入物周围组织的炎症状况.
- 细胞因子在免疫反应和组织修复中起着至关重要的作用.
- 了解PID中的细胞因子概况对于诊断和管理至关重要.
研究的目的:
- 在患有PID的患者中,研究血清细胞因子的表达水平和临床意义,特别是瘤亡因子-alpha (TNF-α),干白素 (IL) -6,IL-10和转化生长因子-beta1 (TGF-β1).
- 为了确定PID发生和进展的潜在生物标志物.
主要方法:
- 从31名PID患者和31名对照组的血清样本使用ELISA分析了细胞因子水平.
- 记录了临床参数,包括修改后的斑块指数 (mPLI),修改后的硫出血指数 (mSBI) 和周围植入物探测深度 (PD).
- 进行了统计分析,包括相关性,后勤回归和ROC分析.
主要成果:
- 与对照组相比,患有PID的患者表现出TNF-α,mPLI,mSBI和PD水平显著更高.
- 对照组的TGF-β1水平显著更高.
- TNF-α与mPLI,mSBI和PD呈正相关性,而TGF-β1与mPLI,mSBI和PD呈负相关性.
- 确定TNF-α和PD是PID严重性的显著风险因素.
- 高TNF-α (切断值140 pg/mL) 和PD (切断值4 mm) 显示了PID严重程度的高预测值 (AUC = 0.922).
结论:
- 血清TNF-α和周植入物探测深度 (PD) 作为诊断周植入物疾病发生和进展的有价值的生物指标.
- 这些发现突显了TNF-α作为PID管理的生物标志物的潜力.
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