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Updated: Jul 5, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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紧结的小分子氧化酶2抑制剂 降低细胞内虹素激活

Karishma Kailass1, Dominick Casalena2, Lina Jenane1

  • 1Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6.

Journal of medicinal chemistry
|January 24, 2024
PubMed
概括

研究人员确定了新型的小分子抑制剂,用于激活二氧化碳聚酶2 (CES2),这是一种关键的酶,用于激活氨酸 (CPT-11). 这些CES2抑制剂在胰腺癌治疗中显示出控制CPT-11毒性的潜力.

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