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在败血症中HAT治疗的治疗作用:系统性审查和元分析

Fatemeh Saghafi¹, Zahra Boostani Moghadam², Amin Salehi-Abargouei^3,4

¹Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Current medicinal chemistry

|January 24, 2024

概括

皮,维生素C和胺 (HAT) 治疗在改善败血症结果方面显示出显著的好处,包括减少器官衰竭得分和缩短血管压力剂持续时间. 虽然没有影响整体死亡率,但HAT疗法在队列研究中有效降低了重症监护室 (ICU) 的死亡率.

科学领域:

关键护理医学关键护理医学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

败血症和败血性休克是危及生命的疾病,需要有效的治疗策略.
作为一种潜在的干预措施,建议使用皮,维生素C (酸) 和胺 (HAT) 的联合治疗.

研究的目的:

系统地审查和分析现有文献,以确定HAT治疗在败血症和败血性休克中的疗效.
评估HAT治疗对死亡率,器官功能和其他临床结果的影响.

主要方法:

在PubMed,Scopus,ISI Web of Science和Google Scholar进行了全面的搜索,截至2021年3月.
对临床试验和队列研究分别和聚合进行了元分析.
包括9个临床试验 (1358名参与者) 和9个队列 (339,437名参与者).

主要成果:

在72小时内,HAT治疗显著降低了败血症相关器官衰竭评估 (SOFA) 评分,血管压缩剂持续时间,并改善了前素清除.
队列研究表明,HAT疗法有效地减少了重症监护室 (ICU) 患者的存活率.
在医院死亡率,28至30天死亡率或急性损伤发病率方面没有发现显著差异.

结论:

在败血症患者中,HAT疗法在改善SOFA得分,血管压缩剂持续时间和前素清除方面显示出显著的益处.
队列数据表明,HAT治疗在降低ICU死亡率方面是有效的.
进一步的研究可能是合理的,以探索其对整体死亡率的影响.

关键词:

败血症这是一种败血症.亚斯科布酸是什么亚斯科布酸帽子治疗是一种治疗.这种药物是Hydrocortisone.进行元分析.败血症败血症是什么?冲击冲击冲击冲击冲击冲击系统性审查系统性审查提氨酸是什么提胺是什么维生素C是维生素C的重要组成部分.

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