细胞内膜网膜应激信号在膀癌中的免疫学交叉声
Shun Wan1,2, Kun-Peng Li1,2, Chen-Yang Wang1,3
1Department of Urology, Lanzhou University Second Hospital, Lanzhou, 730000, PR China.
Current cancer drug targets
|January 24, 2024
概括
细胞内膜网膜 (ER) 的压力通过影响瘤免疫力,影响膀癌 (BC) 的进展和耐药性. 针对ER应激通路,特别是通过免疫细胞死亡 (ICD),显示出增强BC治疗中的免疫疗法反应的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 膀癌 (BC) 存在治疗挑战,包括复发和耐药性,特别是在肌肉侵入性膀癌 (MIBC) 中.
- 在MIBC中的瘤免疫微环境往往缺乏足够的免疫细胞,阻碍有效的治疗反应.
- 由微环境因素 (如缺氧) 引起的内质网膜 (ER) 压力与BC进展和治疗抵抗有关.
研究的目的:
- 审查ER压力对影响瘤免疫力的作用及其对BC的影响.
- 探索针对ER压力路径的潜力,以开发新的BC治疗策略.
- 突出ER压力介导免疫细胞死亡 (ICD) 途径在增强免疫治疗中的作用.
主要方法:
- 关于ER压力,瘤免疫力和膀癌的最新研究的文献综述.
- 分析ER压力影响免疫细胞和BC进展的机制.
- 评估自然化合物和针对ER压力的治疗策略.
主要成果:
- ER压力影响BC中的关键细胞过程,包括增殖,自,亡和治疗耐药性.
- 诱导ER压力的天然化合物表现出抗BC特性,尽管效果不如目前的免疫疗法.
- 经ER压力介导的ICD途径是一种有前途的策略,通过促进免疫干性来改善对免疫检查点抑制剂 (ICI) 的反应.
结论:
- ER压力是膀癌免疫性和耐药性的关键因素.
- 针对ER压力路径,特别是通过ICD,提供了一个潜在的治疗途径,以提高BC治疗效率.
- 对ER应激调节的进一步研究可能会导致新的,更有效的膀癌治疗方法.
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