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睡眠在由二 (2-乙基-基) 甲酸盐诱导的精症中的作用

Xiao-Lu Li^1,2, Xiao-Yue Cai^1,2, Xia Ning^1,2

¹Department of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, China.

Environmental science and pollution research international

|January 24, 2024

概括

迪 (2-乙基-基) 甲酸盐 (DEHP) 暴露与睡眠障碍和精子运动率下降有关. 这项研究表明,DEHP破坏了HIF-1通路,影响了GAPDH和AKT1等蛋白质,导致这些健康问题.

科学领域:

环境毒理学环境毒理学
生殖健康生殖健康
睡眠科学睡眠科学

背景情况:

二乙甲 (DEHP) 是一种常见的环境污染物,具有已知的生殖和神经毒性影响.
精子缺血症 (精子流动性低) 和睡眠障碍是严重的健康问题,患病率越来越高.
暴露于DEHP,睡眠障碍和精子质量降低之间的潜在联系在很大程度上仍未被探索.

研究的目的:

为了调查DEHP暴露,睡眠障碍和精液缩症之间的关联.
确定潜在的分子机制,特别是缺氧诱导因子1 (HIF-1) 途径,参与这些效应.
检查DEHP对HIF-1通路内的关键蛋白质的影响.

主要方法:

对国家健康和营养检查调查 (NHANES) 数据库的分析,以将DEHP暴露与睡眠障碍相关联.
在小鼠和虫中进行实验研究,以评估DEHP对睡眠和精子运动性的影响.
利用比较毒基因组学数据库 (CTD) 和STRING数据库来识别HIF-1通路和相互作用的蛋白质.
西部斑点分析用于测量GAPDH,AKT1和EGFR的蛋白质表达水平.

主要成果:

根据NHANES的数据,DEHP暴露与睡眠障碍之间存在关联.
在动物模型中,DEHP暴露导致睡眠障碍和精子运动率下降.
暴露于DEHP可以降低HIF-1通路内的GAPDH和AKT1的蛋白质表达水平.

结论:

暴露于DEHP与睡眠障碍和精症有关.
缺氧诱导因子1 (HIF-1) 途径,涉及GAPDH和AKT1等蛋白质,可能会调解DEHP的不良影响.
这些发现为DEHP,睡眠障碍和男性生殖健康受损之间的机制联系提供了初步证据.

关键词:

动物精子缺血症 (Asthenozoospermia) 是一个疾病.比较性毒基因组学数据库二甲基 (2-乙基-基) 甲酸盐在HIF-1信号通道中,睡眠障碍睡眠障碍睡眠障碍睡眠障碍

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