在发生子宫内膜癌的妇女中,前性收集的患者报告结果的变化
Jennifer A Sinnott1, Elaheh Torkashvand2, Caitlin E Meade2
1Department of Statistics, The Ohio State University College of Arts and Sciences, Columbus, OH, USA.
Journal of cancer survivorship : research and practice
|January 24, 2024
概括
子宫内膜癌患者在诊断时经历了高症状负担,但大多数患者报告的结果在一年内改善到一般人群水平. 随着时间的推移,风险因素会影响症状体验.
科学领域:
- 妇科瘤学 妇科瘤学
- 患者报告的结果
- 癌症的生存率 癌症的生存率
背景情况:
- 子宫内膜癌治疗显著影响患者的生活质量.
- 了解症状轨迹对于有效的患者护理至关重要.
研究的目的:
- 检查患者/治疗特征与患者报告的结果 (PROs) 之间的关联.
- 为了描述接受子宫内膜癌治疗的女性的纵向经验.
主要方法:
- 在基线,手术后6个月和12个月使用NIH PROMIS问卷.
- 评估了焦虑,抑郁,疲劳,睡眠,疼痛,身体功能和社会角色.
- 使用ANOVA和线性混合模型来分析关联.
主要成果:
- 高基线症状负担,大多数PRO在12个月后返回人口平均值.
- 年轻的年龄,特定的保险,糖尿病和吸烟与更高的症状负担有关.
- 侵袭性组织学,晚期或辅助治疗与6个月后更严重的疲劳相关,在12个月后正常化.
结论:
- 对子宫内膜癌的诊断带来了显著的症状负担.
- 大多数PRO措施在治疗后的一年内正常化.
- 识别症状负担的风险因素可以指导支持性护理转诊.
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