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活着的脏捐赠者中骨折风险在捐赠后25年
Hilal Maradit Kremers1,2, Brandon R Grossardt3, Adam R Miller4
1Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
JAMA network open
|January 24, 2024
概括
活着的脏捐赠者整体骨折较少,但脊椎骨折比匹配的对照组更多. 维生素D3补充剂可能有助于减少这些人的脊椎骨折和相关发病率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 整形外科 整形外科 整形外科
- 公共卫生 公共卫生
背景情况:
- 活着的脏捐赠者可能面临由于捐赠后生理变化的骨折风险增加.
- 这些变化包括质量减少,血清1,25-二基维生素D的降低,甲状腺上腺激素水平升高.
研究的目的:
- 为了比较活体脏捐赠者的整体和特定部位骨折的发生率,与精心匹配的对照对比.
- 确定活体脏捐赠对骨健康的潜在长期影响.
主要方法:
- 一项调查研究涉及2132名活着的脏捐赠者和2014年基于人口的非捐赠者对照.
- 参与者完成了有关骨健康和骨折史的调查.
- 标准化发病率比率 (SIRs) 用于比较骨折率.
主要成果:
- 与对照组相比,活着的脏供体的整体骨折率 (SIR,0.89) 显著降低.
- 然而,活着的脏捐赠者有明显更高的脊椎骨折率 (SIR, 1.42).
- 平均随访时间约为捐赠后25年或索引日期.
结论:
- 活体脏捐赠与整体骨折风险降低有关,但脊椎骨折风险增加.
- 像维生素D3补充等干预措施可能会减轻脊椎骨折的发生率和患者的发病率.
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