在一小时内重复测量血红蛋白质量:可行性,可靠性,并比较卧卧的三个设备
Andreas Breenfeldt Andersen1, Thomas Christian Bonne2, Nikolai Baastrup Nordsborg2
1Department of Public Health, Research Unit for Exercise Biology, Aarhus University, Aarhus, Denmark.
Scandinavian journal of clinical and laboratory investigation
|January 24, 2024
概括
使用一氧化碳 (CO) 再呼吸的重复血红蛋白质量测量是可以立即实现的. 血红蛋白质量在两个设备之间是可比的,但在半自动设备中更高,特别是当遵循特定的CO损失校正建议时.
科学领域:
- 生理学 生理学 生理学
- 肺部医学 肺部医学
- 临床测量 临床测量
背景情况:
- 通过一氧化碳 (CO) 重呼吸进行重复血红蛋白质量测量,由于建议测量间隔较长以防止CO积累,因此存在后勤挑战.
- 现有的方案需要显著的时间差距,影响重复血红蛋白质量评估的效率.
研究的目的:
- 调查执行立即,连续的CO-再呼吸程序的可行性和可靠性,以测量血红蛋白质量.
- 为了比较从三种不同的CO再呼吸装置获得的血红蛋白质量值的可比性.
主要方法:
- 55名健康参与者完成了222次重复的CO-再呼吸程序.
- 十名参与者接受了一项随机交叉试验,其中使用玻璃螺旋计,半自动设备或三通进行了三次CO-再呼吸程序.
- 在随机试验中,顺序测量分隔24小时 (第一个和第二个) 和5-10分钟 (第二个和第三个).
主要成果:
- 进行双重CO-再呼吸程序后,立即导致血红蛋白质量小,统计学上显著下降 (3 ± 22 g,p < 0.05),典型误差为1.1%.
- 碳氧血球蛋白水平平均为10.9±1.3%.
- 在玻璃螺旋计和三通装置之间,血红蛋白质量测量结果相似,但在半自动装置中,血红蛋白质量测量结果大约高出6% (50克). 当应用特定于设备的CO损失校正建议时,差异增加到13% (100克).
结论:
- 为了测量血红蛋白质量,即时的顺序性CO再呼吸程序是可行的和可靠的.
- 在玻璃螺旋仪和三通装置之间,血红蛋白质量值是可比的.
- 半自动设备产生更高的血红蛋白质量值,差异由特定设备的CO损失校正协议放大.
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