灰色/白质对比度与第一发精神分裂症认知表现之间的关系
Haruko Kobayashi1,2, Daiki Sasabayashi1,2, Tsutomu Takahashi1,2
1Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Cerebral cortex (New York, N.Y. : 1991)
|January 24, 2024
概括
精神分裂症患者在早期疾病阶段表现出皮质内髓的减少,由较高的灰色/白色物质对比度表明. 这一发现与认知缺陷相关,这表明髓化问题会影响早期精神分裂症.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 尸体解剖后的研究表明,精神分裂症患者的髓化受损.
- 目前尚不清楚肌形成异常是否存在于早期或随着时间的推移而进展.
研究的目的:
- 通过使用灰色/白质对比度 (GWC) 来研究在第一发精神分裂症 (FESz) 中的皮层内髓化.
- 探索GWC与FESz患者的临床/认知变量之间的关系.
主要方法:
- 使用磁共振成像 (MRI) 来评估GWC.
- 包括63名FESz患者和77名健康对照 (HC).
主要成果:
- 与HC相比,FESz患者在部,顶部,部和岛屿区域的GWC显著更高.
- 较高的GWC与疾病持续时间,药物持续时间,发病年龄以及较差的执行和口头学习表现有关.
结论:
- 升高的GWC表明,在精神分裂症的早期阶段,皮层内髓减少.
- 皮层内髓缺乏可能是FESz.认知障碍的基础.
相关概念视频
01:30Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
01:27Language and Cognition
346
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
346