家庭抵抗训练对化疗相对剂量强度和结肠癌耐受性的影响:FORCE随机对照试验
Bette J Caan1, Justin C Brown2, Catherine Lee1
1Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Cancer
|January 24, 2024
概括
家庭抵抗训练 (RT) 没有改善化疗剂量强度,也没有减少结肠癌患者的毒性. 这项研究发现,与治疗坚持或症状管理的通常护理相比,RT没有显著的益处.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 临床试验 临床试验
背景情况:
- 结肠癌患者在辅助化疗期间经常经历剂量限制性毒性,影响治疗坚持和生存.
- 相对剂量强度 (RDI) 对治疗疗效至关重要,但可以受到化疗副作用的影响.
- 患者报告的结果和治疗坚持是癌症护理的关键考虑因素.
研究的目的:
- 调查家庭抵抗训练 (RT) 是否改善了接受辅助化疗的结肠癌患者的RDI.
- 与常规护理 (UC) 相比,评估RT对患者报告的毒性的影响.
主要方法:
- 一个多中心随机对照试验 (RCT) 涉及181名接受术后化疗的结肠癌患者.
- 参与者被随机分配为每周两次在家进行渐进性RT或常规护理 (UC) 在化疗期间.
- 在研究结束后,UC组接受了在线炼计划.
主要成果:
- 在RT组 (79%) 和UC组 (82%) 之间没有观察到平均相对剂量强度 (RDI) 的显著差异.
- 力量训练并没有显著减少患者每周出现的中度至重度症状的数量.
- 随机化后的时间并没有显著改变RT对整体症状负担的影响.
结论:
- 家庭抵抗训练不支持作为化学疗法的辅助,以改善结肠癌患者的计划治疗强度.
- 目前的证据并不表明RT显著减轻化疗相关的毒性或改善治疗方案的遵守.
- 可能需要进一步的研究来探索这种患者群体的替代或优化炼干预措施.
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