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Updated: Jul 5, 2025

Generation of Mice Derived from Induced Pluripotent Stem Cells
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内生逆转录病毒在小鼠胚胎中形成多能性规范

Sergio de la Rosa1, María Del Mar Rigual1, Pierfrancesco Vargiu2

  • 1Growth Factors, Nutrients and Cancer Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

Science advances
|January 24, 2024
PubMed
概括

内源逆转录病毒 (ERV) 和MERVL-gag蛋白通过控制多能因素OCT4和SOX2.2来调节胚胎发育. 这确保了正确的细胞形成的关键性全能到多能过渡.

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