雌激素对心肌转换后的修饰和女性心脏功能的影响
Samantha K Shorthill1, Timothy L M Jones2, Kathleen C Woulfe2
1Division of Kinesiology and Health, University of Wyoming, Laramie, WY, USA.
Canadian journal of physiology and pharmacology
|January 24, 2024
概括
男人和女人的心力衰竭 (HF) 风险是相同的,但表型不同. 翻译后修改 (PTMs) 和雌激素
科学领域:
- 心血管科学 心血管科学
- 医学中的性别差异.
- 分子心脏病学分子心脏病学
背景情况:
- 心力衰竭 (HF) 在一生中影响男性和女性,但在HF表型中观察到明显的基于性别的差异.
- 男性更常见地被诊断出具有减少喷射分数的HF,而女性则表现出具有保留喷射分数的HF的更高倾向.
- 驱动这些性别特异性HF表型的潜在机制仍然不完全理解.
研究的目的:
- 审查心力衰竭 (HF) 病理生理学的关键性别差异.
- 描述心脏生理学中新型心肌转化后修饰 (PTMs) 的作用.
- 探索雌激素对PTMs在HF发育的背景下对雌激素的调节影响,特别是在女性中.
主要方法:
- 本综述综合了关于高频性差异的当前文献.
- 它检查了翻译后修改 (PTM) 对肌纤维纤维蛋白功能的贡献.
- 讨论了雌激素在调节PTM中的作用及其对HF发展的影响.
主要成果:
- 在HF患病率和表型方面,性别差异很大.
- 肌纤维蛋白的翻译后修饰 (PTMs) 与性别特异性HF发育有关.
- 雌激素对PTM的影响为HF的性别差异提供了潜在的机制,特别是在绝经后的老年女性中.
结论:
- 对女性心脏健康的进一步研究至关重要.
- 不同的分子机制是心力衰竭的性别差异的基础.
- 研究PTM和雌激素调节为女性高血压提供了潜在的治疗途径.
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