空气污染与头癌的发病率增加有关:全国代表性的生态研究
Henrique Ochoa Scussiatto1, Kerstin M Stenson2, Samer Al-Khudari2
1Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA; Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, IL, USA.
暴露于细颗粒物 (PM2.5) 与更高的口腔和喉癌率有关. 这项研究分析了国家数据,以了解空气污染与头癌之间的关联.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 关于暴露于细颗粒物 (PM2.5) 和头癌 (HNC) 之间的联系存在相互矛盾的发现.
- 之前的研究并没有最终确定PM2.5和HNC发展之间的明确关联.
研究的目的:
- 分析PM2.5暴露与各种头癌的发病率之间的关系.
- 在美国的全国代表性生态样本中调查这种关联.
主要方法:
- 利用了SEER计划数据 (2011-2019) 针对美国608个县的HNC发病率.
- 使用卫星和气象数据与验证模型估计的PM2.5暴露.
- 雇佣了灵活的半非参数回归,调整了社会人口统计因素,吸烟和酒精摄入量.
主要成果:
- 增加的PM2.5暴露与更高的口腔和喉癌发病率有关 (IRR=1.04,p=0.02).
- 对于食道,嘴唇和桃体癌症观察到关联,尽管在二次分析中没有一致维持.
- 在调整为多重测试和OLS回归后,主要发现仍然存在.
结论:
- 在美国,高的PM2.5空气污染水平与整体口腔和喉癌的发病率增加有关.
- 这项生态研究强调了空气质量与特定的HNC亚型之间的重要联系.
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