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可编程光切换微囊可从微流体进行精确和定制的药物输送
Buyun Guo1,2, Tianao Chen3,4, Xianglong Hu3,4
1Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230026, China.
ACS applied materials & interfaces
|January 24, 2024
概括
研究人员开发了可光切换的微囊 (PMC),用于精确的药物输送. 这些智能材料使用紫外线可见光提供受控释放,显示了针对癌症治疗和栓塞的前景.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 精准医学需要先进的药物输送系统,可以在时间,空间和剂量上进行控制.
- 响应刺激的智能材料越来越多地用于有针对性的药物输送.
- 通过微流体制造的响应型微囊显示出显著的潜力.
研究的目的:
- 开发UV可见光循环介导的可光切换微囊 (PMCs),用于精确,定制的药物释放.
- 调查PMCs用于控制治疗剂输送的动态透性切换能力.
- 为了证明PMCs在可模式化癌细胞治疗中的治疗效果.
主要方法:
- 使用可编程脉冲空气动力学打印 (PPAP) 制造PMC.
- 在PLGA外内封装磁纳米粒子和多克索鲁比 (DOX).
- 利用紫外线和可见光循环控制药物释放和磁场去除.
主要成果:
- PMCs显示出高精度的时间,空间和剂量控制的 doxorubicin 释放.
- 为药物释放模式开发了一种经过实验验证的理论模型.
- 通过紫外线辐射激活的有效模式癌细胞治疗被证明.
- 在处理后,PMCs被外部磁场成功地去除.
结论:
- PMCs为量身定制的药物输送和栓塞治疗提供了一个多功能平台.
- 该技术整合了栓塞,按需药物输送,磁性启动和成像特性.
- 对于未来的定制可编程药物释放应用和癌症治疗,PMC具有前景.
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