基于西斯普拉丁和细菌外聚糖的生物结合物具有减少副作用:癌症治疗的新建议
Gian Carlo D Angelo de Queiroz1, Fernanda Carolina Ribeiro Dias2, Sandra Maria de Torres3
1Programa de Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos, Universidade Federal Rural de Pernambuco, UFRPE, Recife, PE, Brazil.
概括
这项研究探讨了西斯 (CDDP) 和外聚糖 (EPS) 生物结合物作为一种不太有毒的癌症治疗方法. 与单独的CDDP相比,生物结合物显示出强大的抗瘤作用,降低了组织毒性.
科学领域:
- 生物结合化学 生物结合化学
- 纳米医学是一种纳米医学.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 西斯普拉丁 (CDDP) 化疗具有显著的毒性.
- 乳酸细菌外聚糖 (EPS) 提供潜在的健康益处.
- 开发更安全的CDDP替代品对于癌症治疗至关重要.
研究的目的:
- 合成和评估CDDP和EPS的生物结合物.
- 评估CDDP-EPS生物结合物的细胞毒性,毒性和抗瘤功效.
- 为了研究生物结合物的潜力作为生物相容的化疗剂对抗肉瘤180.
主要方法:
- 合成西斯丁 (cis-[Pt(NH3) 2 ((Cl) 2)) 和CDDP-EPS生物结合物.
- 在体外和体内评估急性毒性和细胞毒性.
- 在患有80型肉瘤的小鼠中对抗瘤疗效的评估,包括组织病理学分析.
主要成果:
- CDDP-EPS生物结合物表现出低至中度细胞毒性和中度急性毒性.
- 在体内研究显示,与对照组相比,瘤质量回归率为38%,与CDDP相比,回归率为41%.
- 组织病理学分析表明,生物结合物减少了肝脏的变化,并将膜变化最小化.
结论:
- CDDP-EPS生物结合物显示了增强的生物相容性.
- 这种新的成分作为一种强大的化疗剂,具有较低的组织毒性.
- 这些发现支持开发基于EPS的生物结合物,以改善癌症治疗.
关键词:
癌症 癌症 癌症 癌症西斯-亚米诺基基克洛洛普拉提纳II.牛乳杆菌发酵 (Lactobacillus fermentum) 是一种植物.药品化学 药品化学 是一个金复合体是一种金复合体.肉瘤 180 180 的情况.更多相关视频
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