青少年的社会受害,默认模式网络连接,以及类似精神病的经历
Abhishek Saxena1, Shangzan Liu2, Elizabeth D Handley1
1University of Rochester, United States of America.
Schizophrenia research
|January 24, 2024
概括
社会受害在青少年中显著增加了类似精神病的经历 (PLE),部分由默认模式网络 (DMN) 调解. 这突显了DMN在精神病风险路径中的作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 社会受害 (SV) 和神经连接的改变与精神病类似体验 (PLE) 有关.
- 将SV与精神病风险联系在一起的机制,特别是神经通路,仍未得到充分探索.
研究的目的:
- 通过默认模式网络 (DMN) 和突出网络 (SAN) 的改变,调查社会受害 (SV) 是否会提升类似精神病的经历 (PLE).
- 检查这些神经网络在SV和PLE之间的关联中扮演的调解角色.
主要方法:
- 利用了来自青少年大脑认知发展 (ABCD) 研究的两年随访数据.
- 采用VS的潜在因子分析和神经网络通路的同时调解分析.
- 进行跨种族群体的多组测试,以评估差异性影响.
主要成果:
- 在潜伏的社会受害因素和PLE结果之间发现了显著的关联.
- 默认模式网络 (DMN) 部分调解了SV和PLE之间的关系.
- 突出网络 (SAN) 没有显示出显著的调解效应.
- 多组分析显示,黑人,西班牙裔和白人青少年之间的DMN调解类似,尽管SV经验有差异.
结论:
- 社会受害者是与青少年精神病类似经历增加相关的重要因素.
- 默认模式网络在从社会受害到精神病风险的途径中发挥着部分调解作用.
- 调查结果强调了解决社会受害问题的重要性,以减轻精神病风险,特别是通过针对社会认知神经网络的干预措施.
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