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捐赠肝脏评估中的偶然发现:单个中心的经验

Iván A González¹, Omer Saeed¹, Mohamed Mustafa¹

¹Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America.

Annals of diagnostic pathology

|January 24, 2024

概括

肝脏捐赠者的偶然发现,如胆道瘤和焦点结节性增生,发生在7.3%的病例中. 在冷部位评估期间的错误诊断导致了不合理的移植丢弃,突出了精确的移植前评估的必要性.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
手术病理学手术病理学

背景情况:

在手术期间的咨询对于肝脏捐赠者资格至关重要.
移植前评估旨在确定与肝脏捐赠相关的潜在风险.

研究的目的:

描述肝脏捐赠者的偶然病理发现.
评估这些发现对器官处置和潜在的错误诊断的影响.

主要方法:

从262名肝脏捐赠者 (2010-2022) 进行的369次手术内咨询的回顾性审查.
对捐赠者的临床病理学特征进行分析,并进行偶然发现.
在病理学评估后,对器官配置的审查.

主要成果:

在19名捐赠者 (7.3%) 的22例 (5.9%) 病例中发现了偶然发现.
常见的肝脏内发现包括胆管哈马托马,真菌感染和焦点结节性增生.
错误地将良性病变诊断为恶性病变导致了移植丢弃,以及错误的肥胖症评估.

结论:

肝脏捐赠者的偶然发现可能被低估.
准确的冷截面评估对于防止不必要的移植拒绝至关重要.
真菌感染可能会影响移植后的免疫抑制策略.

关键词:

临床决策的过程进行捐赠者评估.冷部分的部分.偶然发现偶然发现肝脏移植是什么?肝移植是什么?

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