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在患有二次难治性肺胸部的患者中使用石泥腹膜:一项2期研究
Hideo Saka1, Masahide Oki2, Yoshikane Yamauchi3
1Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, 4-1-1, Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan; Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1, Sannomaru, Naka-ku, Nagoya, Aichi 460-0001, Japan; Department of Respiratory Medicine, Matsunami General Hospital, 185-1 Dendai, Kasamatsu-cho, Hashima-gun, Gifu, 501-6062, Japan.
石灰粘液斑症有效治疗不适合进行手术的老年患者的二次肺胸部. 这种微创手术的成功率很高,主要的副作用是可控的疼痛.
科学领域:
- 肺部病理学 肺部病理学
- 胸部外科手术 胸部外科手术
- 临界护理医学 临界护理医学
背景情况:
- 二次性肺胸炎通常会影响老年人,原因是潜在的疾病.
- 对于心脏功能障碍或其他器官效率低下的患者来说,手术修复通常是不可行的.
- 斑膜切除术为高危患者的难治性肺胸部管理提供了一个非手术替代方案.
研究的目的:
- 评估二次性肺胸病的滑石泥腹腔检查的疗效和安全性.
- 为了确定在不符合手术条件的患者中,石斑膜切除术的成功率.
主要方法:
- 研究了一组31名患有不可手术的二次难治性肺胸部患者的队列.
- 无菌滑石 (4g) 被悬浮在盐溶液中,并通过管道插入到腔中.
- 主要终点是在手术后30天内移除排水管.
主要成果:
- 在82.1%的患者 (23/28) 中,塔尔克泥斑可使排水管在30天内被移除.
- 这一成功率明显超过了预定义的值 (36.0%,p < 0.0001).
- 报告的最常见的不良事件是疼痛,发生在39.3%的患者中.
结论:
- 石灰泥斑是治疗难治的二次肺胸炎的有效治疗方法.
- 该程序与轻微而可控的副作用有关,主要是疼痛.
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