炎症生物标志物与慢性鼻炎与鼻的疾病控制之间的相关性
Eugenio De Corso1, Silvia Baroni2,3, Stefano Settimi1,4
1Unit of Otorhinolaryngology and Head-Neck Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
International forum of allergy & rhinology
|January 24, 2024
概括
鼻分泌物和组织中的中白素-5 (IL-5) 和calprotectin水平可以帮助识别严重的慢性鼻炎与鼻息肉 (CRSwNP) 患者. 喘和NSAID加重的呼吸道疾病也是不受控制的疾病的关键指标.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 呈现出与内型相关的多种治疗反应.
- 与CRSwNP严重程度相关的生物标志物数据有限.
- 这项研究调查了IL-5和calprotectin作为潜在的严重性和控制生物标志物.
研究的目的:
- 评估IL-5和calprotectin在定义CRSwNP严重性的有用性.
- 确定生物标志物,以区分受控制与不受控制的CRSwNP.
- 为了将生物标志物水平与疾病严重程度和治疗结果相关联.
主要方法:
- 一项涉及81名CRSwNP患者的病例控制研究,他们之前接受过手术,并接受了鼻内类固醇治疗.
- A组包括39名不受控制的患者 (SNOT-22 ≥40);B组包括42名受控制的患者 (SNOT-22 <40).
- 在鼻分泌物和多组织中测量IL-5和calprotectin.
主要成果:
- 在不受控制的CRSwNP患者 (A组) 中,在分泌物和组织中发现显著更高的IL-5和calprotectin水平.
- 增加之前的手术与鼻分泌物中较高的IL-5和calprotectin水平相关.
- 多变量分析确定了喘,NSAID加重的呼吸道疾病 (NSAID-ERD) 和IL-5作为无法控制疾病的显著预测因素.
结论:
- 喘,NSAID-ERD和鼻分泌物/组织中的IL-5是识别严重CRSwNP的有价值指标.
- 在不受控制的患者中观察到高卡尔蛋白蛋白和中性友好水平,特别是那些先前进行过多次手术的患者.
- 这些生物标志物可能有助于个性化CRSwNP的治疗策略.
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