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Updated: Jul 5, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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EXO1保护BRCA1缺陷细胞免受毒性DNA病变的影响

Bert van de Kooij1, Anne Schreuder2, Raphael Pavani3

  • 1Department of Human Genetics, Leiden University Medical Centre, Leiden 2333 ZC, the Netherlands; Department of Medical Oncology, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.

Molecular cell
|January 24, 2024
PubMed
概括

缺乏BRCA1的细胞依赖EXO1进行DNA修复. 准EXO1可能是治疗BRCA1突变癌症的新策略,因为其损失会导致DNA损伤的积累.

关键词:
这就是BRCA1的原因.DNA双链断裂修复的修复方法时间 EXO1 EXO1癌症 癌症 癌症 癌症 癌症同类的重组组合.单链回火是一种单链回火.合成杀伤性 合成杀伤性

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