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Updated: Jul 5, 2025

Generation of Induced Pluripotent Stem Cells from Muscular Dystrophy Patients: Efficient Integration-free Reprogramming of Urine Derived Cells
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Generation of Induced Pluripotent Stem Cells from Muscular Dystrophy Patients: Efficient Integration-free Reprogramming of Urine Derived Cells

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对NDUFS4患者细胞的直接神经重编程识别了未展开的蛋白质反应,作为一种新的一般重编程障碍

Giovanna Sonsalla1, Ana Belen Malpartida2, Therese Riedemann3

  • 1Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg 85764, Germany; Biomedical Center Munich, Physiological Genomics, LMU Munich, Planegg-Martinsried 82152, Germany; Graduate School of Systemic Neurosciences, BMC, LMU Munich, Planegg-Martinsried 82152 Germany.

Neuron
|January 24, 2024
PubMed
概括

线粒体功能障碍阻碍了直接的神经元重编程. 抑制未折叠的蛋白质反应可以改善人体细胞的转化,为神经系统疾病提供新的治疗策略.

关键词:
李氏综合征 (Leigh综合征) 是一种星球细胞是星球细胞.直接的神经系统重编程线粒体中的线粒体.不折叠的蛋白质反应反应

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