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心理压力诱导的微生物代谢物英多尔-3-乙酸盐破坏肠道细胞系的承诺

Wei Wei¹, Yali Liu², Yuanlong Hou³

¹State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Cell metabolism

|January 24, 2024

概括

心理压力通过改变细菌对肠道产生影响,导致印-3-酸盐 (IAA) 的产生,从而损害肠道干细胞的分化. 补充α-谷氨酸可能会防止压力诱导的肠道损伤.

科学领域:

神经胃肠病学神经胃肠病学
微生物组研究微生物组研究
干细胞生物学干细胞生物学

背景情况:

大脑 - 肠轴对健康至关重要,但导致肠道疾病的压力诱导的沟通通路径尚未完全理解.
心理压力可以引发肠道上皮的不适应性变化.

研究的目的:

阐明心理压力影响肠道干细胞 (ISC) 的机制及其分化.
确定与压力相关的肠道功能障碍的潜在治疗标.

主要方法:

研究了同情输出和肠道对应器在应激反应中的作用.
测量了英多尔-3-酸盐 (IAA) 生产及其对ISC线粒体功能的影响.
在压力模型中评估α-甲酸补充剂的治疗潜力.
在患者中,便IAA水平与精神困扰和肠道功能障碍相关.

主要成果:

心理压力增加了肠道Lactobacillus murinus,导致更高的英多尔-3-酸盐 (IAA) 产量.
细菌IAA破坏了ISC线粒体的生物能量,破坏了分泌细胞系的承诺.
口服α-谷氨酸补充剂增强了ISC分化,并防止了压力诱导的肠损伤.
在患有精神困扰的患者中观察到便IAA水平升高,与肠道功能障碍相关.

结论:

一个微生物介导的大脑-肠代谢轴通过细菌IAA将心理压力与受损的ISC血统承诺联系起来.
针对这种途径,可能是α-甲酸,为压力驱动的肠-大脑并发症提供了治疗策略.

关键词:

牛乳杆菌 (Lactobacillus) 是一种细菌.大脑与身体之间的沟通.肠-大脑轴肠-大脑轴炎症性肠病是一种炎症性肠病.肠道干细胞是什么?肠道干细胞是什么?微生物的新陈代谢线粒体呼吸系统的呼吸过程心理压力心理压力托的代谢物是托的代谢物.

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