潜在冗余的随机对照试验的流行率和与之相关的因素:一个横截面研究
Qingping Yun1, Minqing Lin2, Yuanxi Jia1
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Journal of clinical epidemiology
|January 24, 2024
概括
大约12.7%至17.1%的最近的元分析包括冗余的随机对照试验 (RCT). 这强调了在启动新的RCT之前需要审查现有证据,以避免重复.
科学领域:
- 临床研究方法论 临床研究方法论
- 证据综合 证据综合
- 生物统计学 生物统计学
背景情况:
- 在元分析中冗余的随机对照试验 (RCT) 代表了资源的低效使用,可能会延迟可靠证据的合成.
- 系统性审查和元分析对于总结研究结果至关重要,但包含不必要的试验可能会损害其完整性和效率.
研究的目的:
- 确定含有潜在冗余RCT的元分析的流行率.
- 在元分析中确定与冗余RCT存在相关的因素.
主要方法:
- 一项横截面研究分析了从主要数据库中2020-2021年发布的4500个引用的随机样本.
- 符合条件的元分析 (n=448) 仅将RCT结合为主要结果.
- 潜在冗余的RCT被定义为那些在累积元分析效应估计变得统计学上可靠一年后开始的RCT,通过试验顺序分析进行评估.
主要成果:
- 超过12.7%的元分析包含潜在冗余的RCT,在低异质性元分析中,患病率达到17.1%.
- 这些冗余的RCT占试验的38.5%和受影响的元分析参与者的30.3%.
- 冗余性在对药物干预的元分析,疗效结果,超过5次RCT的RCT和最早RCT报告有意义的发现时更常见.
结论:
- 最近大量的元分析包括潜在的冗余RCT,这强调了需要进行彻底的系统审查,以证明新的试验是合理的.
- 确定与冗余相关的特定场景可以为试验人员,资助机构,伦理委员会和编辑提供信息,以提高研究效率和证据质量.
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