甲状腺功能对接受ART治疗的人的子女神经发育的影响:前性队列研究
Haofeng Wang1,2, Yuting Peng2,3, Xinru Xia1,2
1Clinical Center for Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
The Journal of clinical endocrinology and metabolism
|January 24, 2024
概括
在辅助怀孕中,母亲的亚临床甲状腺功能低下与1岁女孩的沟通能力下降有关. 建议早期治疗亚临床甲状腺功能低下症,以获得更好的婴儿神经发育结果.
科学领域:
- 生殖医学 生殖医学
- 内分泌学 在内分泌学.
- 发育神经科学的发展神经科学.
背景情况:
- 母亲的甲状腺激素对于胎儿的神经发育至关重要.
- 甲状腺功能障碍会影响自发怀孕中后代的发育.
- 有限的研究存在于甲状腺疾病和神经发育在辅助生殖.
研究的目的:
- 为了检查母亲甲状腺疾病和通过辅助生殖怀孕的婴儿的神经发育之间的联系.
- 在辅助生殖技术 (ART) 周期期间识别与母亲甲状腺功能障碍相关的潜在风险.
主要方法:
- 在中国江苏进行的前性纵向出生队列研究.
- 包括729名接受ART治疗的妇女,在治疗前进行甲状腺功能测试.
- 使用贝利-III查试验评估母亲的甲状腺功能 (抗体,自由甲状腺素,甲状腺素) 和婴儿神经发育.
主要成果:
- 患有亚临床甲状腺功能低下症 (SCH) 的母亲的婴儿的接受性沟通得分明显较低 (β = -.63,P = .013).
- 这种关联在雌性后代 (β = -.87,P = .018) 中显著,但在雄性后代 (β = -.44,P = .145) 中没有显著.
- 在怀孕后的婴儿中,没有观察到正常甲状腺功能和阳性抗体的显著差异.
结论:
- 在辅助怀孕中,亚临床甲状腺功能低下与1岁婴儿,特别是女婴的沟通能力下降有关.
- 建议在整个怀孕期间服用SCH的药物,无论甲状腺自身抗体状况如何.
- 强调在辅助生殖中监测和管理母亲甲状腺功能对于婴儿神经发育的最佳发展的重要性.
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