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非编码RNA和外体非编码RNA在血管炎中的作用:叙述性综述

Xiuming Tang¹, Jiajuan Guo¹, Feng Qi¹

¹Department of Cardiology, The affiliated hospital to Changchun University of Chinise Medicine, Changchun, Jilin 130021, China.

International journal of biological macromolecules

|January 24, 2024

概括

血管炎的发病包括表观遗传失调. 非编码RNA和外体是这些罕见的血管疾病的关键参与者,为研究提供了新的见解.

科学领域:

免疫学免疫学免疫学
遗传学遗传学是一个
分子生物学分子生物学

背景情况:

血管炎是一组罕见的系统性炎症性血管疾病,原因不明.
虽然研究了遗传学,但表观遗传失调越来越被认为是免疫媒介疾病 (如血管炎) 的因素.
非编码基因组,特别是非编码RNA,在生物过程和疾病中起着关键的调节作用.

研究的目的:

总结非编码RNAs在血管炎病变发生中的作用.
突出外体在血管炎的发展和进展中的参与.
提供关于血管炎表观遗传因素的当前理解的概述.

主要方法:

在血管炎中对非编码RNA (lncRNA,miRNA,circRNA) 的现有研究进行文献综述和综合.
对研究的分析,研究细胞外囊泡的功能,特别是外生体,在血管炎相关的炎症和自身免疫过程中.
检查证据,将表观遗传失调与血管炎病原体联系起来.

主要成果:

各种非编码RNA被认为是血管炎发病的重要调节者.
外体被确定为关键的细胞外囊泡,可能调解炎症,内皮功能障碍和其他血管炎的病理过程.
表观遗传机制,包括非编码RNA失调,越来越多地被认为是血管炎的贡献者.

结论:

非编码RNA和外基因组代表了血管炎复杂病变的关键分子参与者.
了解这些表观遗传和膀机制对于推进血管炎病因和治疗的研究至关重要.
对非编码RNA和外体的进一步研究可能会揭示血管炎的新型治疗点.

关键词:

在表观遗传学上,表观遗传学是表观遗传学.异构体是什么? 异构体是什么? 外构体是什么?没有编码的RNAs.血管类型血管类型

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