母亲在出生前期吸烟对后代多动症 (ADHD) 的因果影响:一项两样本的门德尔随机化研究
1School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an 710049, China.
Journal of affective disorders
|January 24, 2024
概括
母亲在出生前期吸烟 (MSAB) 显著增加后代注意力缺陷/多动症障碍 (ADHD) 的风险. 这项研究证实了因果关系,强调了需要产前护理和干预措施来减轻ADHD风险.
科学领域:
- 遗传学和发育神经科学
- 公共卫生和流行病学
背景情况:
- 以前的研究表明,母亲在出生前吸烟 (MSAB) 和后代注意力缺陷/多动症障碍 (ADHD) 之间存在联系.
- 现有的研究主要集中在MSAB对后代ADHD的因果作用上.
研究的目的:
- 研究母亲在出生前期吸烟对后代注意力缺陷/多动症发展的因果关系.
- 为有针对性的产前干预提供证据,并为临床评估提供信息.
主要方法:
- 使用大规模遗传研究的总结统计数据进行了门德尔的随机化分析.
- 关于母亲在出生前期吸烟的数据 (MSAB) 包括391,992名参与者,而ADHD数据涉及246,888名参与者.
- 采用了五种分析方法,以逆方差加权 (IVW) 为主要方法.
主要成果:
- 母亲在出生前期吸烟 (MSAB) 被证实是后代多动症 (ADHD) 的重要危险因素 (OR: 2.54).
- 这种联系在男性和女性后代以及在不同的ADHD诊断中被观察到,包括童年,晚期诊断和持续的ADHD.
- 在最终分析中没有发现显著的异质性.
结论:
- 确立了母亲在出生时吸烟和后代ADHD之间的因果关系.
- 这些发现强调了在ADHD评估和干预中考虑产前MSAB暴露的重要性.
- 未来的研究应该探索母亲吸烟对ADHD发育的剂量依赖影响.
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