来自Eupatorium fortunei上空部分的生物活性单烯酸和烯酸
Lei Miao1, Shu-Ting Wang1, Quan-Hao Wei1
1School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Phytochemistry
|January 24, 2024
概括
这项研究从Eupatorium fortunei中分离了39种甲基醇和乙烯衍生物,包括新型化合物和二元体. 一些衍生物通过激活Nrf2信号通路,表现出抗激素活性和减轻氧化应激.
科学领域:
- 自然产品化学 自然产品化学
- 有机化学 有机化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 富国 (Eupatorium fortunei) 是一种生物活性化合物的植物来源.
- 硫醇和乙芬衍生物是具有多种生物活性的自然产品类别.
- 了解植物化合物的化学多样性和生物活性对于药物发现至关重要.
研究的目的:
- 从Eupatorium fortunei的上空部分中分离和描述化学成分.
- 阐明新型乙醇和乙芬衍生物的结构.
- 评估分离化合物的初步生物活性,包括抗激素和抗炎作用,以及它们对氧化应激通路的影响.
主要方法:
- 使用色谱技术分离化合物.
- 通过全面的光谱数据分析 (NMR等) 阐明结构. ) 的情况.
- 计算方法包括密度函数理论 (DFT) 用于NMR计算和电子圆二元论 (ECD) 用于绝对配置确定.
- 修改的莫舍尔法用于确定特定化合物的绝对配置.
- 在体外测定抗激素活性,氧化物 (NO) 生产抑制和Nrf2信号通路激活.
主要成果:
- 隔离了39种蒂摩尔和阿塞托芬衍生物,包括18种以前未被描述的化合物.
- 通过胺键连接的新型单聚二元体和通过 Ester 键连接的单聚 - 基杂交体被确定.
- 通过ECD计算和修改的莫舍尔方法确定了几个化合物的绝对配置.
- 对以前报告的化合物的结构进行了修订 (15a/15b和22).
- 首次报告了几种化合物的纯天然反体.
- 选择性化合物表现出抗激素和NO生产抑制活性.
- 化合物31通过激活Nrf2信号通路来减轻氧化应激的能力.
结论:
- 这项研究扩大了Eupatorium fortunei已知的化学多样性,揭示了新的分子架构.
- 已识别的化合物,特别是31号化合物,显示出治疗应用的潜力,用于管理与氧化压力相关的疾病.
- 这些发现凸显了对自然产品的持续探索对于新生物活性分子和药物导体的重要性.
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