在免疫功能低下的患者中严重的社区性肺炎
Dara Chean1, Camille Windsor2, Antoine Lafarge1
1Medical Intensive Care Unit, AP-HP Saint-Louis University Hospital, Paris, France.
免疫功能低下的患者面临严重的肺炎风险,通常需要机械通风. 本综述探讨了诊断策略,以改善重症患者的治疗结果.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 由于瘤学,血液学和移植学的进步,免疫受损患者人群的增加.
- 严重的社区性肺炎是重症监护室入院的主要原因,这些患者的死亡率很高.
- 侵袭性机械通风 (高达60%) 和医院死亡率 (40-50%) 的高率与免疫受损个体的严重肺炎有关.
研究的目的:
- 对患有重症肺炎的重症免疫受损患者的诊断和氧化策略进行审查.
- 评估侵入性与非侵入性管理方法的益处与风险的比率.
- 突出标准化诊断策略在改善结果方面的重要性.
主要方法:
- 关于免疫功能低下患者在社区获得的严重肺炎的当前文献的综述.
- 根据免疫抑制类型分析病原体分布 (细菌,病毒,真菌).
- 讨论诊断方法,包括omics技术.
- 对侵入性和非侵入性通风策略的评估.
主要成果:
- 细菌性肺炎占病例的三分之一,而病毒性和真菌性肺炎则分别占15%.
- 尽管进行了全面的治疗,但仍不确定病因与非常高的医院死亡率有关.
- 对侵入性机械通风的需求很大,相关的死亡率很高.
结论:
- 优化诊断方法对于改善重症肺炎严重免疫受损患者的治疗结果至关重要.
- 该审查评估了在新兴omics技术的背景下侵入性和非侵入性策略.
- 需要一个标准化的诊断途径来降低死亡率和提高患者管理.
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