肝细胞癌的全身疗法:一场革命?
Marta Fortuny1,2,3,4, Marco Sanduzzi-Zamparelli1,2,3, Maria Reig1,2,3,5
1Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
United European gastroenterology journal
|January 24, 2024
概括
肝细胞癌 (HCC) 的全身疗法已经随着高成本的创新,如阿特佐利祖马布加贝瓦西祖马布,进化. 本综述分析了这些高级肝癌治疗的SWOT.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 医学瘤学 医学瘤学
- 翻译研究是翻译研究.
背景情况:
- 肝细胞癌 (HCC) 的全身疗法已经从sorafenib发展到新的组合疗法.
- 创新战略涉及高成本,高收益的方法,具有不断变化的竞争优势.
- 新药的安全性和有效性,如阿特佐利祖马布,贝瓦齐祖马布,特梅利穆马布和杜尔瓦卢马布是关键的考虑因素.
研究的目的:
- 审查肝细胞癌 (HCC) 系统治疗的演变.
- 对当前的HCC系统性治疗进行强项,弱点,机会和威胁 (SWOT) 分析.
- 评估高级肝癌治疗的创新范式.
主要方法:
- 对关键临床试验 (IMBRAVE150,HIMALAYA) 和HCC系统治疗进展的文献综述.
- 分析HCC治疗开发中的战略创新模式.
- 应用于肝细胞癌全身疗法的SWOT框架.
主要成果:
- 索拉费尼布启动了一个高成本的创新趋势,反应率很低.
- 组合疗法 (阿特佐利祖马布/贝瓦西祖马布,特梅利祖马布/杜尔瓦卢马布) 代表了第二波创新.
- 像IMBRAVE150和HIMALAYA这样的试验证实了HCC系统治疗中高风险,高回报的方法.
结论:
- HCC系统治疗的特点是持续的高风险,高回报的创新.
- 了解这些疗法的SWOT对未来的治疗策略至关重要.
- 需要进一步的研究来优化肝癌治疗的疗效和管理肝癌治疗的安全问题.
相关概念视频
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K


