中国成年人糖尿病和慢性病:基于人口的队列研究
Xue Wang1, Lu Chen1, Kexiang Shi1
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
BMJ open diabetes research & care
|January 24, 2024
概括
糖尿病可显著增加中国成年人患慢性病 (CKD) 和其亚型 (包括糖尿病病) 的风险. 早期检测和终身血糖管理对于预防损伤至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 有限的队列证据存在于糖尿病 (DM) 和慢性病 (CKD) 之间的关联,之前的研究往往忽略了特定的亚型.
- 现有的研究经常将患者分类为患有糖尿病病 (DKD) 或CKD,可能缺少疾病进展和风险因素的细微差别.
研究的目的:
- 预期评估糖尿病状况和随机血葡萄糖 (RPG) 与患CKD及其亚型的风险的关联.
- 调查不同糖尿病状态,包括糖尿病前期和控制/不受控制的诊断糖尿病,对CKD发病率的影响.
主要方法:
- 利用了中国Kadoorie生物库的472545名参与者的数据,分析了基线糖尿病和RPG信息.
- 在平均11.8年的随访期间,通过与国家医疗保险系统的联系确定了事件CKD及其亚型.
- 考克斯回归模型用于计算CKD风险的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在随访期间,共有5,417名成年人患有CKD.
- 糖尿病与患CKD (HR=4.52),DKD (HR=33.85) 和血球炎 (HR=1.66) 的风险增加密切相关.
- 没有控制的糖尿病和糖尿病前期,即使在非糖尿病人中具有较高的RPG水平,也与CKD和DKD的更高风险有关.
结论:
- 糖尿病是中国成年人口中CKD,DKD和质炎的重要危险因素.
- 检测到的糖尿病和不受控制的DM构成CKD发展的高风险.
- 糖尿病前期与DKD风险增加有关,这强调了终身持续血糖控制的重要性.
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