患有甲状腺癌的患者自杀风险:系统审查和元分析的协议
Chen Li1, Mengmeng Zhang1, Quan Wang2
1Peking University People's Hospital, Beijing, China.
BMJ open
|January 24, 2024
概括
这项研究调查了甲状腺癌幸存者的自杀风险,解决了与此前相矛盾的发现. 它旨在提供关于甲状腺癌对自杀率的影响的明确证据.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 甲状腺癌的发病率正在上升,特别是在年轻人中.
- 之前关于甲状腺癌幸存者的自杀率的研究产生了不一致的结果.
- 对甲状腺癌过度诊断和过度治疗的担忧需要进一步研究其长期影响.
研究的目的:
- 系统地审查和总结被诊断为甲状腺癌的患者中自杀风险.
- 提供关于甲状腺癌与自杀风险之间的联系的有力的证据.
- 为临床实践和公共卫生战略提供有关甲状腺癌生存率的信息.
主要方法:
- 将对六个主要数据库 (MEDLINE,Embase,Web of Science,PsycINFO,CINAHL,Google Scholar) 进行全面的文献搜索.
- 搜索术语将包括MeSH,子标题和与自杀,癌症和流行病学研究相关的自由单词.
- 标准死亡率 (SMR) 将是主要的结果指标,风险比率和危险比率作为次要指标.
主要成果:
- 数据提取将重点关注详细的自杀信息和死亡率.
- 统计分析将涉及计算SMR,风险比率和危险比率以量化自杀风险.
- 该研究计划在2024年1月31日的搜索日期之后完成.
结论:
- 这一系统性审查将为甲状腺癌患者的心理健康结果提供关键的见解.
- 这些发现将有助于更好地了解与甲状腺癌相关的心理负担.
- 生成的证据将有助于为甲状腺癌幸存者开发有针对性的支持系统.
相关概念视频
01:21Cancer Survival Analysis
348
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
348
01:30Psychosurgery
56
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
56
01:12Hazard Ratio
124
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
124
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
128
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
128