在使用管LISS-IAT方法治疗抗CD38的患者中,出现新的合免疫的风险
Hana Safić Stanić1, Zrinka Kruhonja Galić1, Martina Lukić2
1Department of Immunohematology, Croatian Institute of Transfusion Medicine, Zagreb, Croatia.
概括
接受达拉图姆巴 (抗CD38疗法) 的患者的输血管理是安全有效的. 这项研究没有发现使用试管检测输血匹配红细胞 (RBC) 的患者的新抗体.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 达拉图穆马布向CD38,表达在髓瘤细胞和红细胞上.
- 这可能会在输血管理期间引起泛反应.
- 接受达拉图穆马布治疗的患者需要仔细的免疫血液学检查.
研究的目的:
- 评估对接受抗CD38治疗的患者的输血管理策略.
- 为了确定输血患者与匹配红细胞的安全性和有效性.
- 评估在接受达拉图穆马布治疗的患者中出现新的alloantibodies的发生率.
主要方法:
- 68名接受抗CD38治疗的患者 (2018-2023) 的回顾性研究.
- 输血病史和抗体查的分析.
- 进行了DAT,抗体查 (CAT和管),红细胞基因定型和血清交叉匹配 (CAT和管).
- 在LISS-tube中重新测试了阳性CAT IAT,并在LISS-tube中与表型匹配的单位进行了交叉匹配.
主要成果:
- 抗体查显示了强度可变的泛质化.
- 药物停用后的1-6个月内,泛质化持续存在.
- 在60.6%的患者中观察到阳性DAT;自控是负的.
- 用菲辛治疗的细胞消除了非特异性反应性.
- LISS-tube抗体查和交叉匹配结果是负的,除了3名患有先前存在抗体的患者.
- 没有检测到新的抗体.
结论:
- 在研究小组中没有发现新发现的alloantibodies.
- 输血患者与匹配的红细胞并进行管检测 (IAT/交叉匹配) 是安全有效的.
- 这一政策确保了达拉图穆马布治疗患者的安全输血实践.
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