身体尺寸,饮食质量和表观遗传衰老:截面和纵向分析
Danmeng Lily Li1,2, Allison M Hodge2,3, Lachlan Cribb1
1Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
概括
保持健康的体重和改善饮食质量可能会减缓生物衰老. 饮食质量下降和体重增加可以加速成人表观遗传衰老,但减肥效应需要更多的研究.
科学领域:
- 表观遗传学和衰老研究.
- 营养流行病学 营养流行病学
- 衰老的生物标志物
背景情况:
- 表观遗传年龄是健康,疾病和死亡率的预测因素.
- 将生活方式变化与表观遗传衰老联系在一起的证据有限.
- 了解这些联系可以为促进健康衰老的干预提供信息.
研究的目的:
- 调查体型,饮食质量和表观遗传衰老之间的关联.
- 检查横截面和纵向关系.
- 确定可能影响生物衰老速度的可修改因素.
主要方法:
- 分析了来自墨尔本协作队列研究的1,041名参与者的数据.
- 在两个时间点 (1990-1994年和2003-2007年) 测量DNA甲基化.
- 评估饮食质量 (AHEI-2010,地中海饮食评分,DII) 和身体大小 (体重,腰围,WHR).
- 使用多变量回归模型对五种表观遗传衰老指标 (GrimAge,PhenoAge,PCGrimAge,PCPhenoAge,DunedinPACE) 的评估.
主要成果:
- 体重和表观遗传衰老之间的积极的横截面关联,特别是对于DunedinPACE.
- 体重变化和表观遗传衰老之间的非线性 (U形) 纵向关联;稳定的体重与最慢的衰老有关.
- 饮食质量 (AHEI-2010) 和表观遗传衰老之间的负面,线性关联,无论是横截面还是纵向.
- 体重增加和饮食质量下降与表观遗传年龄的增加有关.
结论:
- 饮食质量下降和体重增加可能会加速中年到老年人的表观遗传衰老.
- 稳定的体重和改善的饮食质量显示出减缓生物衰老的潜力.
- 需要进一步的研究来澄清减肥对表观遗传衰老的影响.
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