Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Brain Imaging01:14

Brain Imaging

232
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
232

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-Performance Multi-Walled Carbon Nanotubes-Organic Passivated Si Solar Cells Enabled by Spatially Selective Harvesting of High-Quality Sponges.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Assessment of diverse deep brain stimulation targets uncovers a common neural pathway for instantaneous antidepressant effects in rats.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Malignant transformation risk and management dilemmas of atypical lobular endocervical glandular hyperplasia: A retrospective cohort study comparing Peutz-Jeghers syndrome versus sporadic cases.

Gynecologic oncology·2026
Same author

GTPBP4 promotes colorectal cancer cell proliferation by positively regulating MYC-driven glycolytic metabolism.

American journal of cancer research·2026
Same author

The MAPK Pathway Coordinates an Immunosuppressive Microenvironment in Colorectal Cancer: A Single-Cell Guided Prognostic Model.

Cancer informatics·2026
Same author

FKBP9 Enhances Colon Cancer Cell Proliferation by Inhibiting GPX4-Mediated Ferroptosis.

Cancer medicine·2026

相关实验视频

Updated: Jul 5, 2025

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

1.8K

改变形状的电极阵列用于最小侵入性的大规模内大脑活动映射.

Shiyuan Wei1,2, Anqi Jiang1, Hongji Sun1

  • 1Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, 100871, China.

Nature communications
|January 24, 2024
PubMed
概括

研究人员开发了一种微创,灵活的电极阵列,用于详细地绘制大脑活动的地图. 这项新技术提供了高分辨率的电皮质谱 (ECoG),用于研究大脑状态和疾病.

更多相关视频

Author Spotlight: Advancing Genetic Epilepsy Studies with Multi-Electrode Array-Based Long-Term Electrophysiological Monitoring of Human Brain Assembloids
06:30

Author Spotlight: Advancing Genetic Epilepsy Studies with Multi-Electrode Array-Based Long-Term Electrophysiological Monitoring of Human Brain Assembloids

Published on: September 27, 2024

1.3K
Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

11.4K

相关实验视频

Last Updated: Jul 5, 2025

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

1.8K
Author Spotlight: Advancing Genetic Epilepsy Studies with Multi-Electrode Array-Based Long-Term Electrophysiological Monitoring of Human Brain Assembloids
06:30

Author Spotlight: Advancing Genetic Epilepsy Studies with Multi-Electrode Array-Based Long-Term Electrophysiological Monitoring of Human Brain Assembloids

Published on: September 27, 2024

1.3K
Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

11.4K

科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 医疗器械 医疗器械

背景情况:

  • 大规模的大脑活动映射对于理解行为的神经机制至关重要.
  • 电皮质谱 (ECoG) 提供高时空分辨率,但受到侵入性和手术风险的限制.
  • 现有的非侵入性技术缺乏详细的大脑状态分析的分辨率和带宽.

研究的目的:

  • 开发一种超薄,灵活,可改变形状的电极阵列 (SCEA),用于最小侵入性,大规模的ECoG映射.
  • 在动物模型中评估SCEA的生物相容性和有效性.
  • 展示SCEA在物理和病理状态期间绘制大脑活动的能力.

主要方法:

  • 开发了一种超薄,灵活的变形电极阵列 (SCEA).
  • 在压缩状态下通过小开口将SCEAs最小侵入性植入皮质表面.
  • 在老鼠中进行MRI和组织学分析,以评估侵入性和慢性生物相容性.
  • 在发作期间和麻醉后出现时,动物和狗的大脑中的ECoG记录.

主要成果:

  • 在小鼠中,SCEAs成功地植入了最小的侵入性,并显示出高的慢性生物相容性.
  • 从动物和狗的大脑中获得了高质量的微型ECoG信号.
  • SCEA揭示了发作期间大脑状态的时空组织,并以高分辨率和带宽出现.

结论:

  • SCEAs为高分辨率的大规模ECoG映射提供了最少的侵入性方法.
  • 与现有的非侵入性方法相比,该技术提供了优越的时空分辨率和带宽.
  • SCEAs是基础大脑研究,理解大脑疾病和开发大脑机器接口的有希望的工具.