在前列腺癌中使用雄激素受体向药物的心血管风险:系统性审查和元分析
Chloe Shu Hui Ong1, Yu Xi Terence Law2, Lin Kyaw2
1Department of Urology, National University Hospital, National University Health System, Singapore, Singapore. chloe.ong@mohh.com.sg.
Prostate cancer and prostatic diseases
|January 24, 2024
概括
针对雄激素受体的药物 (ARTA) 在前列腺癌患者中增加了诸如高血压和心脏病等心脏事件的风险. 在开始ARTA治疗时,仔细的心脏风险管理至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对雄激素受体的向药物 (ARTA) 越来越多地用于前列腺癌.
- 长时间的患者存活导致更高的累积ARTA暴露和副作用,特别是心血管疾病.
- 需要评估与ARTA治疗相关的心脏相关不良事件.
研究的目的:
- 与安慰剂相比,评估在接受ARTA治疗的前列腺癌患者心脏相关不良事件的发生率.
主要方法:
- 在三个数据库中进行了系统的文献搜索.
- 两位独立审稿人使用PICOS模型进行了研究选择.
- 用Cochran-Mantel-Haenszel方法进行了元分析,通过Cochrane风险偏差工具 (RoB 2) 评估质量.
主要成果:
- 在前列腺癌中使用ARTA显著增加了与心脏相关的不良事件的发生率 (RR: 1.56).
- 具体事件包括高血压 (RR: 1.69),缺血性心脏病 (RR: 1.84) 和心律失常 (RR: 1.38).
- 没有观察到心脏骤停或死亡的显著增加 (RR: 1.28).
结论:
- 治疗前列腺癌的ARTA与心脏不良事件的风险较高有关,包括高血压,缺血性心脏病和心律失常.
- 这一发现强调了主动心脏风险管理的重要性.
- 在开始ARTA治疗时建议咨询心脏病专家.
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