皮层调节疼痛中对他人进行帮助的行为
Mingmin Zhang1,2, Ye Emily Wu1,2,3, Mengping Jiang1,2
1Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nature
|January 24, 2024
概括
通过别人的伤口, 帮助缓解疼痛. 大脑前带皮层 (ACC) 在这种对疼痛的亲社会反应中起着关键作用.
科学领域:
- 神经科学
- 动物的行为
- 社会认知
背景情况:
- 在各个物种中都能观察到亲社会性的帮助行为.
- 帮助他人应对痛苦的神经机制在很大程度上是未知的.
研究的目的:
- 调查疼痛的小鼠帮助行为的神经基础.
- 确定与受伤相关的社会反应相关的大脑区域.
主要方法:
- 在小鼠中观察到对受伤的同类动物的 (社会) 行为.
- 使用微内镜成像记录前带皮质 (ACC) 中的神经活动.
- 对ACC进行功能操作以评估其因果作用.
主要成果:
- 小鼠对受伤部位进行向合,从而减轻受伤部位的疼痛.
- ACC神经活动编码了其他人的特定疼痛状态,与一般压力不同.
- ACC活动因果控制目标合金行为.
- 在ACC中,与疼痛相关的帮助的种群编码与allogrooming不同.
结论:
- 前带状皮质对于调节针对性帮助行为至关重要.
- 在ACC中的神经表现区分了与疼痛相关的和与压力相关的亲社会行为.
- 这项研究提供了对同情和帮助的神经基础的见解.
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