对于中等风险的复发性儿童急性淋巴细胞白血病,TBI,埃托波西德和环胺调节
Hideaki Ueki1, Chitose Ogawa2, Hiroaki Goto3
1Department of Pediatric Hematology/Oncology, Japanese Red Cross Narita Hospital, Narita, Japan.
International journal of hematology
|January 24, 2024
概括
与全身辐射,以托胺和环胺调节的全基因造血干细胞移植 (allo-HSCT) 是患有复发性急性淋巴细胞白血病 (ALL) 的儿童可行的和有效的治疗方法. 这种方法在日本队列中显示出高生存率和没有与治疗相关的死亡率.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 儿童复发性急性淋巴细胞白血病 (ALL) 是一个重大的治疗挑战,特别是对于那些有不满意的最小残留疾病 (MRD) 反应的人来说.
- 全基性造血干细胞移植 (allo-HSCT) 已成为改善这一高风险群体结果的关键策略.
- 之前的研究表明,涉及全身辐射 (TBI),埃托 (ETP) 和环胺 (CY) 的调节方案是有效的,促使对它们的联合使用进行调查.
研究的目的:
- 预期评估使用统一调节方案 (TBI + ETP + CY) 的allo-HSCT的疗效和安全性,用于中等风险复发ALL的日本儿童.
- 评估诱导后最小残留疾病 (MRD) 对治疗结果的影响.
- 为了确定与此特定的条件化协议相关的可行性和生存率.
主要方法:
- 进行了一项全国性队列研究 (JPLSG ALL-R08-II),涉及中等风险复发ALL的儿童.
- 患者接受了allo-HSCT与包括TBI,ETP和CY在内的调节方案.
- 监测了植入和移植相关的死亡率,以及无事件存活率和整体存活率.
主要成果:
- 22名患有复发ALL的患者接受了all-HSCT,所有病例都确认了移植.
- 没有观察到与移植相关的死亡率,这表明调节方案的安全性概况有利.
- 三年无事件生存率为86.4%±7.3%,整体生存率为95.5%±4.4%.
结论:
- -HSCT与TBI + ETP + CY调节的结合是日本儿童中等风险复发ALL的可行和安全的治疗选择.
- 这种治疗方法产生了高的生存率,为改善这一儿科患者群体的结果提供了一个有希望的策略.
关键词:
急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.童年 童年 童年 童年环酸胺的使用方法这种类型的Etoposide.移植 移植 移植 移植更多相关视频
11:15Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
7.9K
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.4K
相关概念视频
Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Bone Marrow Sampling and Transplants
331
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
331
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
