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Updated: Jul 5, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
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TXNRD1驱动衰老细胞的先天免疫反应,这对与年龄相关的炎症有影响

Xue Hao1, Bo Zhao1,2, Martina Towers1

  • 1Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature aging
|January 24, 2024
PubMed
概括

铁素还原酶1 (TXNRD1) 通过激活cGAS-STING通路,驱动无菌炎症和组织衰老,独立于其酶活性. 针对TXNRD1-cGAS相互作用可能会抑制炎症.

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