炎症对癌症和冠状动脉疾病之间的关联的影响
Mingzhuang Sun1,2, Shaoning Zhu1, Yihao Wang1
1Department of Cardiology, Chinese PLA General Hospital, #28 Fuxing Rd, Beijing, 100853, China.
BMC cardiovascular disorders
|January 24, 2024
概括
新诊断的癌症与更严重的冠状动脉疾病 (CAD) 有关. 这种关联在炎症水平高的患者中尤其强烈,这表明炎症在癌症-CAD关系中起着作用.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 炎症研究 炎症研究
背景情况:
- 癌症和冠状动脉疾病 (CAD) 经常同时发生.
- 癌症与CAD的解剖学严重程度之间的直接关系还没有得到充分研究.
- 炎症对癌症-CAD联系的影响需要进一步调查.
研究的目的:
- 为了检查新诊断的癌症和CAD的解剖学严重程度之间的关联.
- 为了确定炎症是否调节癌症和CAD严重程度之间的关系.
主要方法:
- 374名接受冠状动脉血管造影 (CAG) 的癌症患者的倾向性得分与1122名非癌症对照相匹配 (1:3).
- 使用SYNTAX评分 (SXscore) 量化CAD解剖学严重程度.
- 炎症通过中性粒细胞与淋巴细胞的比率 (NLR) 来评估.
主要成果:
- 癌症诊断与CAD (SX-高) 的解剖学严重程度增加有显著的相关性.
- 在调整为常见的CAD风险因素后,这种关联仍然很重要.
- 癌症和严重CAD之间的联系在高NLR (炎症) 患者中更加明显.
结论:
- 癌症与冠状动脉疾病的较大解剖严重程度有关.
- 炎症起着重要作用,加强了癌症和严重CAD之间的关联.
- 向炎症可能对治疗癌症和CAD患者至关重要.
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