甘 lucidum 多糖改善胆固醇胆结石的形成,通过调节胆固醇和胆酸代谢以依赖于FXR的方式调节胆固醇和胆酸代谢
Dan Huang1, Shuang Shen1, Qian Zhuang1
1Digestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Chinese medicine
|January 24, 2024
概括
甘光多糖 (GLP) 通过调节胆酸代谢和抑制FXR信号,防止胆固醇胆结石 (CG) 的形成. 这表明GLP是CG疾病的潜在预防策略.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胆固醇胆结石 (CG) 疾病是一种与胆固醇超和相关的普遍疾病.
- 甘光多糖 (GLP) 在代谢障碍方面表现有前途,但其在CG形成中的作用尚不清楚.
研究的目的:
- 调查GLP在改善石质性饮食 (LD) 诱导的CG形成中的作用.
- 阐明GLP对胆固醇和胆酸 (BA) 代谢作用的潜在机制.
主要方法:
- 给小鼠进行正常饮食,LD或LD与GLP.
- 分析了与胆固醇和BA代谢相关的基因表达 (RT-qPCR) 和蛋白质水平 (西部涂抹).
- 量化了体内BA度,内微生物群和血清硫化 (H2S).
主要成果:
- GLP显著减少了CG的形成,降低了胆囊胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆胆
- GLP抑制了Farnesoid X受体 (FXR) 信号传递,调节了肝脏胆固醇和BA合成,并改变了阴茎BA组成.
- GLP改善了肠道失调,降低了血清H2S,其保护作用被FXR激动剂逆转.
结论:
- 通过依赖FXR的途径,GLP通过调节胆固醇和BA代谢来改善CG的形成.
- GLP代表了预防CG疾病的潜在治疗策略.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Cholesterol: Significance and Regulation
548
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
548
Overview of Fatty Acid Metabolism
30.7K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.7K
Inflammation
53.4K
Overview
53.4K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
208
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
208
Lipids: Dietary Sources and Requirements
741
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
741


