寻求治疗的行为和心血管疾病在男性中使用合成雄激素类固醇:一个横截面研究
Hans Christian Bordado Henriksen1,2, Ingrid Amalia Havnes2,3, Marie Lindvik Jørstad1,4
1Anabolic Androgenic Steroid Research Group, Section for Clinical Addiction Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
寻求治疗的类固醇类固醇 (AAS) 用户表现出更高的心血管疾病 (CVD) 症状,如呼吸障碍和心脏功能下降. 令人担忧的是,大多数患有严重心血管疾病症状的人从未为AAS相关问题寻求帮助.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 类固醇类固醇 (AAS) 使用与各种健康问题有关,包括心血管疾病 (CVD).
- 了解AAS使用,相关发病率和医疗保健参与之间的关系对于公共卫生干预至关重要.
研究的目的:
- 调查与使用类固醇类固醇 (AAS) 相关的发病率,特别是心血管疾病 (CVD) 和与卫生服务的接触之间的联系.
- 为了比较寻求治疗和非寻求治疗的AAS用户之间的卫生服务参与.
主要方法:
- 一项涉及90名男性,目前或以前使用AAS至少12个月的横截面研究.
- 根据网络问卷,参与者被分为寻求治疗 (TSG) 和非寻求治疗 (非TSG) 的组.
- 健康评估包括对心血管疾病症状的临床采访,血液测试,血压测量和胸前心脏回声学.
主要成果:
- 与非TSG相比,在目前的AAS使用者中,TSG表现出更高的呼吸障碍患病率 (50% vs. 7%) 和显著更多的左心室喷射分数 (LVEF) 减少与左心室缩 (LVH) (36% vs. 9%) 和高血压 (55% vs. 19%) 的情况.
- 目前的AAS使用者中有很大比例的确定的LVEF<50% (44%) 或LVH (43%) 从未因AAS相关的不良影响而寻求医疗服务.
- 在总样本中,异常的肝脏和功能参数是常见的,但在不同组之间没有差异.
结论:
- 当前AAS使用者寻求治疗的行为与呼吸障碍增加和诊断的心血管疾病相关.
- 值得关注的是,大多数有严重心血管疾病的客观症状的AAS使用者没有为AAS相关的健康问题寻求治疗.
- 这突显了AAS使用者经历心血管不良影响的医疗保健参与中的关键差距.
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