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开发基于Leishmania tarentolae的冷化真核细胞无蛋白质表达系统

Juan Alfaro-Palma1, Wayne A Johnston1, James Behrendorff1,2

  • 1ARC Centre of Excellence in Synthetic Biology, Centre for Agriculture and the Bioeconomy, School of Biology and Environmental Science, Queensland University of Technology, Brisbane, QLD 4001, Australia.

ACS synthetic biology
|January 25, 2024
PubMed
概括

我们开发了一种冷化版本的Leishmania tarentolae表达 (LTE) 系统,使室温储存成为可能. 这一创新使得真核细胞的无细胞蛋白质表达更容易获得,即使在偏远的地方.

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Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...