怀孕,分娩和剖腹产后新生儿微生物组早期发育中的母亲微生物组:一项前性的纵向研究
Philipp Foessleitner1, Petra Pjevac2,3, Sonja Granser1
1Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, and Comprehensive Center for Pediatrics (CCP), Medical University of Vienna, Vienna, Austria.
Acta obstetricia et gynecologica Scandinavica
|January 25, 2024
概括
在怀孕晚期,母亲的微生物组保持稳定. 在剖腹产产后出生的婴儿中,新生儿微生物组是在出生后建立的,而不是之前,并且受到子宫外环境的影响.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 怀孕研究 怀孕研究
背景情况:
- 在怀孕的第三个三个月期间,母亲的微生物组组成.
- 在剖腹产后影响新生儿微生物组建立的因素.
研究的目的:
- 描述怀孕后期母亲微生物组的变化.
- 为了确定新生儿微生物组发育的决定因素,剖腹产后.
主要方法:
- 在孕期第三季度收集母亲的阴道和直肠样本.
- 在出生和分娩后2-3天收集了子宫内,胎盘和新生儿样本 (口腔,皮肤,).
- 分析了微生物群落,使用16S rRNA基因扩增序列测序.
主要成果:
- 孕妇的阴道和直肠微生物组在妊娠第三季度没有显著变化.
- 在子宫内,胎盘或早期新生儿样本中没有发现显著的微生物特征.
- 新生儿微生物组在产后2-3天迅速建立,显示出显著的差异.
结论:
- 在健康怀孕的第三季度,母亲的微生物组是稳定的.
- 新生儿微生物组的发展主要是由产后暴露于子宫外环境所驱动的.
- 没有发现新生儿产前微生物殖民的证据.
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