对于Hirschsprung疾病中手术后肠球炎的节段炎症反应的影响
Yalım Benibol1, Ayşe Mine Önenerk Men2, Ali Ekber Hakalmaz1
1Cerrahpasa Faculty of Medicine, Department of Pediatric Surgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.
肠道中高白素-1β (IL-1ß) 水平与希尔施普隆相关肠球炎 (HAEC) 有关. 较高的IL-1β在关节段是Hirschsprung病患者HAEC的危险因素.
科学领域:
- 胃肠病学 胃肠病学
- 儿科手术 儿科手术
- 免疫学 免疫学 免疫学
背景情况:
- 赫施普隆病 (Hirschsprung disease,简称HD) 是一种影响大肠的先天性疾病.
- 希尔施普朗相关肠球炎 (HAEC) 是HD的一种严重并发症.
- 促炎性细胞因子在肠道炎症中起作用.
研究的目的:
- 研究在患有HD的患者中特定的益炎性细胞因子和HAEC之间的关系.
- 为了确定HAEC发展的潜在风险因素.
主要方法:
- 分析了30名接受手术的HD患者,根据肠球炎 (EC) 的存在和时间分类.
- 利用免疫组织化学来评估肠道部分的互白素-1β (IL-1ß),瘤坏死因子-α (TNF-α) 和互白素-6 (IL-6) 的水平.
- 在具有和没有EC的组和对照组之间比较细胞因子染色.
主要成果:
- 与对照组相比,与肠球炎患者的节区观察到显著更高的IL-1β染色 (p=0.012).
- 过渡区 (第三组) 的TNF-α和节区 (第一组) 的IL-1ß的增加也明显高于对照组 (p=0.030,p=0.020).
结论:
- 关节性肠段IL-1β水平的增加与HAEC有关.
- 诊断时的年龄较大和高于20%的IL-1β染色在关节段被确定为HAEC的危险因素.
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