磁性和可注射的铁合液体金属用于控制运动和光热/电磁疗法
Yingjie Cao1, Linlin Fan2, Jianye Gao1
1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. jliubme@tsinghua.edu.cn.
Journal of materials chemistry. B
|January 25, 2024
概括
这项研究引入了一种新的铁注入液态金属 (Fe/LM) 生物材料. 这种可注射材料为未来的医疗应用提供了精确的磁性准和有效的光热/磁热疗法.
科学领域:
- 生物材料工程 生物材料工程
- 纳米技术 纳米技术
- 医学物理 医学物理
背景情况:
- 液体金属 (LM) 是多功能多功能材料.
- 结合金属颗粒可以增强生物医学应用的LM特性.
- 开发具有可控制药物输送系统的向疗法至关重要.
研究的目的:
- 开发和评估可注射的铁颗粒增强液态金属 (5%Fe/LM) 生物材料.
- 评估其针对性传递,成像和治疗应用的潜力.
- 研究其用于癌症治疗的光热和磁热特性.
主要方法:
- 5%Fe/LM生物材料的制造.
- 使用CT成像评估可注射性和放射性透明度.
- 在ex vivo肠道模型中评估磁性操纵.
- 在体外细胞毒性测试对生物安全.
- 理论建模和数值模拟用于热分析.
- 在子中使用NIR激光和AMF进行体内温度变化评估.
主要成果:
- 5%Fe/LM成功制备,证明了CT成像的注射性和放射性透明性.
- 外部磁铁精确地控制了5%Fe/LM在模拟肠道环境中的位置.
- 在体外试验证实了5%Fe/LM的生物安全性和低毒性.
- 在NIR激光或AMF下观察到体内显著的温度升高,表明有效的光热和磁热能力.
结论:
- 开发的5%Fe/LM生物材料显示出针对性交付和最小侵入性热疗法的显著前景.
- 它的注射性,磁性可控制性和治疗潜力的独特组合使其成为一种新的功能生物材料.
- 需要进一步的研究来探索其在光热和磁热治疗中的全部临床潜力.
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