在甲状腺癌中植物性天然产品的研究进展
Qiujing Du1,2, Weidong Shen1
1The Affiliated Jiangyin People's Hospital of Nantong University, Jiangyin, China.
Frontiers in chemistry
|January 25, 2024
概括
天然化合物显示出作为替代甲状腺癌治疗方法的希望. 研究审查了昆素,白醇和黄素的证据,探索它们在甲状腺癌治疗中的潜在益处和安全性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺癌 (TC) 是一种常见的内分泌恶性瘤,检测率越来越高.
- 目前的治疗方法,如甲状腺切除术和放射性治疗,提供了良好的预后,但对幸存者有副作用和长期挑战.
- 天然产品正在成为TC的潜在替代疗法,提供方便,负担得起和可接受性.
研究的目的:
- 审查选定的天然产品对甲状腺癌的药理学影响.
- 评估天然产品作为TC的替代治疗剂的潜力.
- 探索基于天然产品的TC疗法的生物可用性和药物安全性等挑战.
主要方法:
- 用于选天然产品的文献搜索和数据库预测.
- 对自然产品对TC的疗效进行了体外,体内和有限的人类证据的审查.
- 分析特定化合物的药理作用,如奎尔塞丁,基因斯坦和白醇对TC的影响.
主要成果:
- 精选的天然产品,包括奎尔塞丁,基尼斯,阿皮基宁,卢特奥林,克里辛,米瑞,白醇,黄素和诺比丁,在TC治疗的临床前和一些临床研究中显示出有前途.
- 来自细胞和动物水平研究的证据支持这些化合物的潜力.
- 在TC中确定了潜在的治疗应用,以及生物可用性和安全性等挑战.
结论:
- 自然产品代表了替代甲状腺癌治疗策略的有希望的途径.
- 需要进一步的研究来优化这些化合物的使用,解决生物可用性和安全性问题.
- 基于天然产品的疗法可以补充或提供传统TC治疗的替代方案.
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