COVID-19康复性等离子疗法:长期影响
Hyunah Yoon1, Yi Li2, Keith S Goldfeld2
1Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Open forum infectious diseases
|January 25, 2024
概括
COVID-19康复性血 (CCP) 并没有改善长期的急性后续症 (PASC) 症状. 性别,年龄和感染时间等人口因素显著影响了住院18个月后PASC症状报告.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- COVID-19治疗对SARS-CoV-2感染 (PASC) 后急性后续的长期影响仍然基本上是未知的.
- 研究COVID-19康复性血 (CCP) 对PASC症状和一般健康的影响对于了解长期康复至关重要.
研究的目的:
- 评估COVID-19康复性血 (CCP) 治疗在减轻SARS-CoV-2感染 (PASC) 后急性后续症状中的18个月疗效.
- 评估CPC对一般健康和患者报告结果测量信息系统 (PROMIS) 在住院COVID-19患者的长期影响.
主要方法:
- 在CONTAIN-Extend研究中,来自CONTAIN COVID-19试验的281名参与者在住院后的18个月内进行了跟踪.
- 数据收集包括症状调查,全球健康评估和生物样本分析.
- 使用多变量回归分析来评估CPC治疗臂与PASC症状之间的关联,并根据相关共变量进行调整.
主要成果:
- 在CCP和安慰剂组之间没有观察到PASC症状或PROMIS得分的显著差异.
- 女性性别,年龄在45-64岁之间,以及在2020年4月至6月期间的入学,与增加的一般症状和较差的身体健康有关.
- 与白人参与者相比,西班牙裔和黑人参与者报告身体健康状况较差.
结论:
- COVID-19康复性血 (CCP) 治疗对SARS-CoV-2感染 (PASC) 后急性后续症状或18个月的整体健康状况没有持久的益处.
- 包括性别,年龄和急性感染时间在内的人口因素是COVID-19住院后长期症状报告和健康结果的重要预测因素.
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